Psilocybin lacks antidepressant-like effect in the Flinders Sensitive Line rat
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منابع مشابه
Decreased in vivo α2 adrenoceptor binding in the Flinders Sensitive Line rat model of depression.
Depression is a debilitating heterogeneous disorder and the underlying mechanisms remain elusive. Alterations in monoaminergic neurotransmission, including noradrenergic, have been implicated in the etiology of depression. Although depression is difficult to model in animals, the availability of animal models with face, predictive and construct validity permits more in-depth investigations resu...
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Approximately 25 years have passed since the first publication suggesting the Flinders sensitive line (FSL) rat as an animal model of depression. At least 6 years of research on these rats was completed before that seminal paper, and there has been a steady stream of publications (130+) over the years. The present review will focus on several issues not previously covered in earlier reviews, su...
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Neuropeptide S (NPS) and its receptor (NPSR) have been implicated in the mediation of anxiolytic-like behaviour in rodents. However, little knowledge is available regarding the NPS system in depression-related behaviours, and whether NPS also exerts anxiolytic effects in an animal model of psychopathology. Therefore, the aim of this work was to characterize the effects of NPS on depression- and...
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ژورنال
عنوان ژورنال: Acta Neuropsychiatrica
سال: 2019
ISSN: 0924-2708,1601-5215
DOI: 10.1017/neu.2019.15